Strained Systems/Angle Strain

Complex molecules containing strained systems (e.g. deviation from ideal bond angles, anti-Bredt olefins, etc.)

subtopics: small rings (3 or 4 atoms, 27.5 – 26.3 kcal/mol strain energy), medium rings (8 – 11 atoms, 9.7 – 11.3 kcal/mol strain energy), anti-Bredt’s rule natural products (i.e. paclitaxel)

13 November, 2019: bridgehead olefins

(Kendall Heitmeier)

Month A

Month B

11 December, 2019: bridgehead olefin

problems

Month A

8 July, 2020: cyclopropanes (Tim McFadden)

Month B

12 August, 2020: cyclopropane problems

10 March, 2021: cyclobutanes

(Kendall Heitmeier)

Month A

Month B

14 April, 2021: cyclobutane

problems