Technical Challenges

challenges associated with isolation, synthesis, purification, characterization (i.e. does the molecule readily epimerize, racemize, or isomerize? Is it difficult to determine relative stereochemistry/absolute stereochemistry? Does the molecule degrade under acidic or basic conditions?)

subtopics: high polarity, high nitrogen-to-carbon ratio, inseparable natural product mixtures/isomers

Month A

9 September, 2020: atropisomers (Jordan Lyles)

Month B

14 October, 2020: atropisomer problems